{"id":432,"date":"2019-11-05T17:48:09","date_gmt":"2019-11-05T16:48:09","guid":{"rendered":"https:\/\/hjerteforeningen.dk\/fagnet\/?p=5343"},"modified":"2024-07-03T10:52:50","modified_gmt":"2024-07-03T10:52:50","slug":"statiner-oeger-ikke-risikoen-for-depression","status":"publish","type":"artikel","link":"https:\/\/hjerteforeningen.dk\/fagnet\/artikler\/alle-artikler\/statiner-oeger-ikke-risikoen-for-depression\/","title":{"rendered":"Statiner \u00f8ger ikke risikoen for depression"},"content":{"rendered":"\t\t
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Tv\u00e6rtimod ser statiner ud til at virke gavnligt ind p\u00e5 depressionssymptomer.<\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Kolesterols\u00e6nkende medicin af typen \u2019<\/span>statiner<\/span>\u2019 har v\u00e6ret under mistanke for\u00a0<\/span>at \u00f8ge patienters risiko for depression.<\/span>\u00a0<\/span>Et nyt studie<\/span><\/a>\u00a0<\/span>g\u00f8r nu op med\u00a0<\/span>myten<\/span>.<\/span>\u00a0<\/span><\/p>

– Den klare konklusion p\u00e5 det her studie er, at<\/span>\u00a0<\/span>patienter\u00a0<\/span>uden tegn p\u00e5 depression ikke udvikler depression under\u00a0<\/span>statinbehandlin<\/span>g<\/span>.<\/span>\u00a0<\/span>Dern\u00e6st er konklusionen, at\u00a0<\/span>statiner<\/span>\u00a0ser ud til at have en positiv effekt p\u00e5 depressive patienter i forhold til deres depressionssymptomer<\/span>,<\/span>\u00a0<\/span>forklarer\u00a0<\/span>Bo\u00a0<\/span>Christenensen<\/span>, professor i almen medicin p\u00e5 Institut for Folkesundhed i \u00c5rhus og praktiserende l\u00e6ge.<\/span>\u00a0<\/span><\/p>

Resultaterne er en stor hj\u00e6lp i klin<\/span>isk praksis\u00a0<\/span>og fjerner en bekymring hos b\u00e5de patienter og sundhedspersonale.<\/span>\u00a0<\/span><\/p>

– Hvis jeg sidder med en patient, der har et mentalt godt helbred og patienten sp\u00f8rger bekymret ind til, om <\/span>statiner<\/span>\u00a0kan p\u00e5virke hum\u00f8ret, kan jeg berolige og sige, at det er der ikke noget, der tyder p\u00e5<\/span>. Det er vigtigt<\/span>,<\/span>\u00a0at patienten kan tr\u00e6ffe sin beslutning p\u00e5\u00a0<\/span>et\u00a0<\/span>solidt grundlag og ikke un\u00f8dvendige bekymringer, <\/span>siger Bo Christensen. <\/span>\u00a0<\/span><\/p>

Han pointerer, at\u00a0<\/span>studiet ikke betyder, at\u00a0<\/span>der er grundlag for at bruge\u00a0<\/span>statiner<\/span>\u00a0til at behandle depressioner med.\u00a0<\/span>\u00a0<\/span><\/p>

– Omvendt, hvis du har en patient med en depression, der samtidig<\/span>\u00a0har gavn af\u00a0<\/span>at f\u00e5 nedsat sit kolesteroltal, er der ingen grund til at v\u00e6re bekymret for at give\u00a0<\/span>statiner<\/span>. Tv\u00e6rtimod kunne det p\u00e5virke depressionen i hensigtsm\u00e6ssig retning, siger Bo Christensen.<\/span>\u00a0<\/span><\/p>

Forskningschef i Hjerteforeningen Gunnar Gislason er begejstret for studiet, der efter hans mening g\u00f8r det af med en sejlivet myte.\u00a0<\/span>\u00a0<\/span><\/p>

– Det er vigtigt at f\u00e5 brudt den her myte omkring <\/span>statiner<\/span> og depression. Vi ved, hvor effektive\u00a0<\/span>statiner<\/span>\u00a0er i forhold til at s\u00e6nke d\u00f8deligheden og nye tilf\u00e6lde af hjertekarsygdomme<\/span>,<\/span>\u00a0og vi har oplevet, at myten om depression og\u00a0<\/span>statiner<\/span> er blevet brugt som argument for ikke at s\u00e6tte patienter i behandling, og det er uheldigt, siger han<\/span>.<\/span>\u00a0<\/span><\/p>

Studiet er en metaanalyse af 10\u00a0<\/span>egnede\u00a0<\/span>studier<\/span><\/a>, der ser p\u00e5 effekten af\u00a0<\/span>statiner<\/span>\u00a0p\u00e5 omkring 2500 patienter i alt. Hos patienter, der i forvejen havde en depression, var\u00a0<\/span>statiner<\/span>\u00a0overordnet set bedre end placebo til at reducere symptomer p\u00e5 depressionen. Hos patienter, der ikke i forvejen havde en depression, s\u00e5s ingen effekt.\u00a0<\/span><\/p>

\u00a0<\/span><\/p>

Inflammation har betydning for depression<\/span><\/h3>

At\u00a0<\/span>statiner<\/span>\u00a0ligefrem har en positiv indvirkning p\u00e5 depressionssymptomer kan umiddelbart virke overraskende, men Bo Christensen forklarer, at det h\u00e6nger godt sammen med den nyeste<\/span>\u00a0viden p\u00e5 omr\u00e5det:<\/span>\u00a0<\/span>\u00a0<\/span><\/p>

– Resultaterne passer godt med de seneste teorier om <\/span>udvikling af\u00a0<\/span>depression, hvor inflammation er helt\u00a0<\/span>centralt<\/span>\u00a0forst\u00e5et p\u00e5 den m\u00e5de, at\u00a0<\/span>ved depression er der\u00a0<\/span>et forh\u00f8jet inflammationsniveau i kroppen<\/span>.\u00a0<\/span>Vi ved\u00a0<\/span>netop, at\u00a0<\/span>s<\/span>tatiner<\/span>\u00a0p\u00e5virker\u00a0<\/span>inflammationsniveauet<\/span>,<\/span>\u00a0og p\u00e5 den m\u00e5de\u00a0<\/span>passer\u00a0<\/span>resultaterne godt med\u00a0<\/span>teorien<\/span>\u00a0omkring udvikling af depression<\/span>.<\/span>\u00a0<\/span>\u00a0<\/span><\/p>

– Det <\/span>her kan v\u00e6re med til at\u00a0<\/span>afd\u00e6kke teorien omkring inflammation\u00a0<\/span>og depression, og det bliver sp\u00e6ndende<\/span>\u00a0at se<\/span>, om\u00a0<\/span>man\u00a0<\/span>i fremtiden\u00a0<\/span>vil udvikle\u00a0<\/span>nye l\u00e6gemidler\u00a0<\/span>til behandling af depression<\/span>\u00a0p\u00e5 den baggrund,<\/span>\u00a0siger Bo Christensen.<\/span>\u00a0<\/span>\u00a0<\/span><\/p>

\u00a0<\/span><\/p>

Mange myter er forbundet med\u00a0<\/span>statiner<\/span>\u00a0<\/span><\/h3>

B\u00e5de Bo Christensen og Gunnar Gislason giver andre eksempler p\u00e5 hvordan myter om bivirkninger af kolesterols\u00e6nkende medicin er blevet manet i jorden igen.<\/span>\u00a0<\/span><\/p>

– <\/span>Jeg har set mange eksempler p\u00e5 myter om bivirkninger af kolesterols\u00e6nkende medicin, der er opst\u00e5et blandt andet som f\u00f8lge af skr\u00e6kkampagner i medierne. For nylig blev det for eksempel afkr\u00e6ftet, at <\/span>statiner<\/span>\u00a0\u00f8ger risikoen for\u00a0<\/span>h<\/span>\u00e6moragisk<\/span>\u00a0apopleksi<\/span>, hvor\u00a0<\/span>s<\/span>tatiner<\/span>\u00a0t<\/span>v\u00e6rtimod vist<\/span>e<\/span>\u00a0sig at neds\u00e6tte risikoen<\/span>, <\/span>siger Bo Christensen.<\/span>\u00a0<\/span><\/p>

– Det samme g\u00e6lder for muskelsmerter, <\/span>hvor man for nylig har fundet ud af, at de\u00a0<\/span>formodentlig ikke er s\u00e5 hyppige, som man ellers\u00a0<\/span>har\u00a0<\/span>troe<\/span>t<\/span>\u00a0i relation til behandling med kolesterols\u00e6nkende medicin<\/span>,<\/span>\u00a0og hvor mange\u00a0<\/span>patienter\u00a0<\/span>er g\u00e5et ud af\u00a0<\/span>behandlingen p\u00e5 grund af muskelsmerter<\/span>, siger Gunnar Gislason.<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Tv\u00e6rtimod ser statiner ud til at virke gavnligt ind p\u00e5 depressionssymptomer. <\/p>\n","protected":false},"author":21,"featured_media":605,"template":"","meta":{"_acf_changed":false},"global-tag":[27,96,127],"class_list":["post-432","artikel","type-artikel","status-publish","has-post-thumbnail","hentry","global-tag-behandling","global-tag-depression","global-tag-statiner"],"yoast_head":"\nStatiner \u00f8ger ikke risikoen for depression - For fagfolk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hjerteforeningen.dk\/fagnet\/artikler\/alle-artikler\/statiner-oeger-ikke-risikoen-for-depression\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Statiner \u00f8ger ikke risikoen for depression - For fagfolk\" \/>\n<meta property=\"og:description\" content=\"Tv\u00e6rtimod ser statiner ud til at virke gavnligt ind p\u00e5 depressionssymptomer.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hjerteforeningen.dk\/fagnet\/artikler\/alle-artikler\/statiner-oeger-ikke-risikoen-for-depression\/\" \/>\n<meta property=\"og:site_name\" content=\"For fagfolk\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-03T10:52:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hjerteforeningen.dk\/fagnet\/wp-content\/uploads\/sites\/2\/2023\/05\/Ung-smartphone.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1852\" \/>\n\t<meta property=\"og:image:height\" content=\"1234\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimeret l\u00e6setid\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutter\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/hjerteforeningen.dk\/fagnet\/artikler\/alle-artikler\/statiner-oeger-ikke-risikoen-for-depression\/\",\"url\":\"https:\/\/hjerteforeningen.dk\/fagnet\/artikler\/alle-artikler\/statiner-oeger-ikke-risikoen-for-depression\/\",\"name\":\"Statiner \u00f8ger ikke risikoen for depression - 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